Interaction between biocomponents and surface modified fluorinated polyimide

We investigated the effect of surface modification of fluorinated polyimide (6FDA-6FAP) on the interaction with plasma proteins and living cells. The surface of 6FDA-6FAP could be modified by various methods and surface-rubbing method was one of the most useful techniques. The surface of 6FDA-6FAP obtained by rubbing method showed nano-ordered roughness and different plasma protein adsorption behavior from non-modified (unrubbed) surface, which adsorbed IgG selectively among plasma proteins through the Fc fragment by hydrophobic interaction. Consequently, the adhesion of platelets and proliferation of living fibroblast cells on rubbed 6FDA-6FAP showed different mode compared with non-modified unrubbed 6FDA-6FAP surface. The fibroblast cells aggregated and formed multicellular spheroid on rubbed 6FDA-6FAP and showed excellent collagen production.