Colloidal systems made of biotransesterified α, β and γ cyclodextrins grafted with C10 alkyl chains

Alpha (α), beta (β) and gamma (γ) fatty ester cyclodextrins with C10 alkyl chains (CD-C10) on the secondary face were synthesized using an enzymatic pathway involving thermolysin as a biocatalyser. Depending on the formulation, these new cyclodextrin derivatives self-assembled and formed nanostructures presenting the ability to entrap diazepam, a lipophilic model drug. The loaded nanoparticles were tested for in vitro release of the drug molecule. Biphasic release profiles were observed with a pronounced delayed release in the case of γCD-C10 nanoparticles, associated to a low initial burst effect. These results are encouraging and may constitute the basis for designing novel multifunctional nanoscale systems made up with versatile cyclodextrin derivatives.