A new zwitterionic imprinted polymer sensor using ethylenediamine tetraacetic acid and chloranil precursors for the trace analysis of l-histidine

A new zwitterionic (‘gemini’ like) l-histidine imprinted polymer, based on poly (ethylenediamine tetraacetic acid-co-chloranil), was synthesized for the modification of hanging mercury drop electrode. The imprinted polymeric film at the electrode surface facilitated l-histidine to be reduced electrochemically, as a consequence of the catalytic action of charge-transfer (chloranil-l-histidine complexation) reaction, to respond the corresponding differential pulse, cathodic stripping voltammetric signal without any cross-reactivity with interferents. The limit of detection (3σ) was found to be 0.128 ng mL− 1 (RSD 0.2%) and results were found to be precise and accurate, without any false-positive contributions from human blood serum samples.