Title of article :
Synthesis, swelling and drug release behavior of poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) hydrogel
Author/Authors :
Chen، نويسنده , , Jun and Liu، نويسنده , , Mingzhu and Liu، نويسنده , , Hongliang and Ma، نويسنده , , Liwei، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
In this study, poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) (poly(DEA-co-NHMAA)) hydrogels were synthesized by changing the initial DEA/NHMAA mole ratio, N,Nʹ-methylenebisacrylamide and total monomer concentration. The thermosensitive and mechanical performances were optimized by altering the above parameters. The hydrogels were characterized by using Fourier transform infrared (FTIR) spectroscope and scanning electron microscope (SEM). In comparison with the PDEA hydrogel, the equilibrium swelling ratio (ESR) and lower critical solution temperature (LCST) of the hydrogels increased with the increase of NHMAA content in the feed. The swelling kinetics was also studied. The release behaviors of the model drug, aminophylline, are found dependent on hydrogel composition and environmental temperature, which suggests that these materials have potential application as intelligent drug carriers.
Keywords :
Drug release , swelling behavior , Hydrogel , Thermosensitive , LCST
Journal title :
Materials Science and Engineering C
Journal title :
Materials Science and Engineering C