Author/Authors :
Denadai، نويسنده , , آngelo M.L. and Da Silva، نويسنده , , Jeferson G. and Guimarمes، نويسنده , , Pedro P.G. and Gomes، نويسنده , , Leonardo Bertolini S. and Mangrich، نويسنده , , Antonio S. and de Rezende، نويسنده , , Edivaltrys I.P. and Daniel، نويسنده , , Izabela M.P. and Beraldo، نويسنده , , Heloيsa and Sinisterra، نويسنده , , Rubén D.، نويسنده ,
Abstract :
Reaction of highly soluble orally active, non-peptide antihypertensive drug losartan with copper(II) leads to the spontaneous formation of a very insoluble 2:1 covalent complex, which self assembles in a hydrophobic supramolecular structure of nanometric dimensions. Thermal analysis showed that Los/Cu(II) complex presents intermediate stability in comparison with its precursors KLos and Cu(OAc)2·H2O. Isothermal titration calorimetry indicated complexation to be a stepwise process, driven by enthalpy and entropy. Zeta potential and DLS measurements showed that it is possible to control the size and charge of nanoprecipitates by adjusting the relative concentration of Los− and Cu(II).
Keywords :
Copper , Losartan , Coordination complex , Stepwise complexation , Control of size , Hydrophobic precipitate
