Title of article
In vitro controlled release of vitamin C from Ca/Al layered double hydroxide drug delivery system
Author/Authors
Gao، نويسنده , , Xiaorui and Chen، نويسنده , , Yong-Le and Xie، نويسنده , , Juan and Yin، نويسنده , , Yaobing and Chang، نويسنده , , Yu-Tao and Duan، نويسنده , , Yancong and Jiang، نويسنده , , Nan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
5
From page
56
To page
60
Abstract
A new drug delivery system for vitamin C (VC), Ca/Al layered double hydroxide (LDH), is demonstrated in this work. VC anions were intercalated successfully in the Ca/Al LDH gallery by a coprecipitation method. The interlayer space of 9.8 Å suggests that VC anions are vertical to the LDH layers in the form of interdigitated bilayer. The loading of VC in LDH is 36.4 wt.%. The thermal stability of VC is significantly enhanced after intercalation. In vitro VC release results show that the release time of VC in a phosphate buffer at pH 7.4 was significantly extended, and the maximal percentage of VC released is 80% of the total. The Avrami–Erofeʹev equation most satisfactorily explains the release kinetics of VC, which is that the release of VC is mainly dominated by the ion-exchange reaction.
Keywords
Layered double hydroxide , Vitamin C , Controlled release , Drug delivery system , thermal stability
Journal title
Materials Science and Engineering C
Serial Year
2014
Journal title
Materials Science and Engineering C
Record number
2104334
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