Title of article :
The induction of nitric oxide response of carp macrophages by transferrin is influenced by the allelic diversity of the molecule
Author/Authors :
Jurecka، نويسنده , , Patrycja and Irnazarow، نويسنده , , Ilgiz and Stafford، نويسنده , , James L. and Ruszczyk، نويسنده , , Aleksandra and Taverne، نويسنده , , Nico and Belosevic، نويسنده , , Miodrag and Savelkoul، نويسنده , , Huub F.J. and Wiegertjes، نويسنده , , Geert F.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
7
From page :
632
To page :
638
Abstract :
The central role of transferrin (Tf) as an iron transporting protein has been extended by observations that modified versions of Tf also participate in the regulation of innate immunity. We report on the isolation of two carp Tf proteins (alleles D and G) to purity using rivanol precipitation and ion-exchange chromatography, and describe the activation of head kidney-derived carp macrophages by cleaved Tf. We demonstrate the superiority of the D-type over the G-type Tf in inducing nitric oxide (NO) and confirm previous observations that full-length Tf cannot induce NO in fish macrophages. We believe that cleaved Tf fragments should be considered to be “alarmins”. We discuss the possibility that parasites such as Trypanoplasma borreli cleave Tf and use Tf fragments to their advantage by modulating the NO induction in carp macrophages.
Keywords :
alleles , Nitric oxide , Carp , Cyprinus carpio , macrophages , Transferrin
Journal title :
Fish and Shellfish Immunology
Serial Year :
2009
Journal title :
Fish and Shellfish Immunology
Record number :
2108505
Link To Document :
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