Title of article :
Parenteral immunization of fish, Labeo rohita with Poly d, l-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses
Author/Authors :
Behera، نويسنده , , T. and Nanda، نويسنده , , P.K. and Mohanty، نويسنده , , C. and Mohapatra، نويسنده , , D. and Swain، نويسنده , , P. and Das، نويسنده , , B.K. and Routray، نويسنده , , P. and Mishra، نويسنده , , B.K. and Sahoo، نويسنده , , S.K.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Immunogenicity of different antigen preparations of outer membrane proteins (OMP) of Aeromonas hydrophila such as Poly d, l-lactide-co-glycolic acid (PLGA) microparticles, oil emulsion, neat OMP and bacterial whole cells were compared through intra-peritoneal injection in fish, Labeo rohita. Among these preparations, PLGA encapsulated antigen stimulated both innate and adaptive immune parameters and the immunogenicity exhibited by PLGA microparticles was significantly higher (p < 0.05) at both 21 and 42 days post-immunization suggesting that the above delivery system would be a novel antigen carrier for parenteral immunization in fish, Labeo rohita
Keywords :
Aeromonas Hydrophila , immune response , Outer membrane proteins , PLGA , Microparticles
Journal title :
Fish and Shellfish Immunology
Journal title :
Fish and Shellfish Immunology
