Author/Authors :
Wang، نويسنده , , Xin and Qiu، نويسنده , , Haiyan and Jin، نويسنده , , Dong and Cui، نويسنده , , Zhigang and Kan، نويسنده , , Biao and Xiao، نويسنده , , Yuchun and Xu، نويسنده , , Yanmei and Xia، نويسنده , , Shengli and Wang، نويسنده , , Hua and Yang، نويسنده , , Jinchuan and Wang، نويسنده , , Xianjun and Hu، نويسنده , , Wanfu and Xu، نويسنده , , Jianguo and Jing، نويسنده , , Huaiqi Shao، نويسنده ,
Abstract :
Serotypes O:3, O:8 and O:9 Yersinia enterocolitica strains carrying virulence determinants are common pathogens causing human infections. In many years of surveillance in China for Y. enterocolitica, no pathogenic O:8 strains have been found where the isolated O:8 serotypes lacked the major virulence genes and in contrast to O:3 and O:9 strains, none of the O:8 isolates were from humans. These O:8 isolates lack ail, ystA, yadA and virF genes but possess the ystB gene and all belong to Biotype 1A. These O:8 strains did not kill mice and could protect immunized mice against challenge with a pathogenic O:8 strain. Compared to the Chinese pathogenic O:3 and O:9 strains which have similar pulsed-field gel electrophoresis patterns, the 39 Chinese O:8 animal and food isolates were different from the pathogenic O:8 reference strains. This suggests the O:8 strains lacking virulence determinants may not disseminate rapidly in humans and are maintained in animal reservoirs; and therefore exhibit higher variance and divergence from the virulent type.
