Title of article
Improved Synthesis of Vasicinone
Author/Authors
-، - نويسنده Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, I.R. IRAN Ziaee, Vahid , -، - نويسنده Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, I.R. IRAN Jalalizadeh, Hasan , -، - نويسنده Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, I.R. IRAN Iranshahi, Mehrdad , -، - نويسنده Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center , Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, I.R. IRAN Shafiee, Abbas
Issue Information
دوفصلنامه با شماره پیاپی 32 سال 2004
Pages
4
From page
33
To page
36
Abstract
-
Abstract
A new, high yielding method for the preparation of vasicinone (7) is described. Reaction of 2-nitrobenzoic acid with N, N¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). Reduction of the latter with 10% Pd-C afforded deoxyvasicinone (4). Reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). Exchange of bromine of 5 with acetoxy followed by hydrolysis gave vasicinone in high yield.
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Serial Year
2004
Journal title
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Record number
2114275
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