Title of article
Detoxification of Aflatoxin B1 by Enzymes Isolated from Armillariella tabescens
Author/Authors
Liu، نويسنده , , Da-Ling and Yao، نويسنده , , Dong-Sheng and Liang، نويسنده , , Ren and Ma، نويسنده , , Lin and Cheng، نويسنده , , Wei-Qiang and Gu، نويسنده , , Lian-Quan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
12
From page
563
To page
574
Abstract
Detoxification of aflatoxin B1 (AFB1) by Armillariella tabescens multienzyme, which was isolated from mycelium pellets of A. tabescens, was confirmed by thin-layer chromatography (TLC) and rat assay. The results of toxicology and pathology studies showed that toxicity of AFB1 was minimized after treatment with A. tabescens multienzyme. The result of the Ames test indicated that the mutagenic activity of multienzyme-treated AFB1 was greatly reduced (or inactivated) compared with that of untreated controls. TLC determinations showed that AFB1 at an initial concentration of 16 μm was completely detoxified (100%) by the fungal multienzyme. The infrared spectrum suggests that the multienzyme is responsible for opening the difuran ring of AFB1.
Keywords
Armillariella tabescens , fungal multienzyme , Detoxification , Aflatoxin B1
Journal title
Food and Chemical Toxicology
Serial Year
1998
Journal title
Food and Chemical Toxicology
Record number
2116217
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