Title of article
In vitro genotoxicity testing of ARASCO® and DHASCO® oils
Author/Authors
Arterburn، نويسنده , , L.M and Boswell، نويسنده , , K.D and Lawlor، نويسنده , , T and Cifone، نويسنده , , M.A and Murli، نويسنده , , H and Kyle، نويسنده , , D.J، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
6
From page
971
To page
976
Abstract
ARASCO® and DHASCO® oils are microbially-derived triglycerides rich in arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids, respectively. Both oils were tested for mutagenic activity in three different in vitro mutagenesis assays. All assays were conducted with and without metabolic activation. Neither ARASCO nor DHASCO oil was mutagenic in the Ames reverse mutation assay using five different Salmonella histidine auxotroph tester strains, nor were the oils mutagenic in the mouse lymphoma TK+/- forward mutation assay. The oils showed no clastogenic activity in chromosomal aberration assays performed with Chinese hamster ovary cells. Based on these assays, neither ARASCO nor DHASCO oils appear to have any genotoxic potential.
Keywords
Docosahexaenoic acid (DHA) , Arachidonic acid (ARA) , Crypthecodinium cohnii , Mortierella alpina , Genotoxicity , single-cell oils
Journal title
Food and Chemical Toxicology
Serial Year
2000
Journal title
Food and Chemical Toxicology
Record number
2116650
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