Title of article :
The evaluation of toxicity and mutagenicity of various drinking waters in the human blood lymphocytes (HULYs) in vitro
Author/Authors :
Ergene، نويسنده , , Serap and Celik، نويسنده , , Ayla and Cava?، نويسنده , , Tolga and K?leli، نويسنده , , Nurcan and Aymak، نويسنده , , Cemil، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
4
From page :
2472
To page :
2475
Abstract :
The aim of the study was to evaluate the toxic and mutagenic effects of bottled purified and natural spring waters for drinking. The study presents the genotoxicologic results of drinking water samples packaged in polyethylene terephthalate (PET) bottles. Genotoxic agents have the potential to interact with DNA and may cause DNA damage. Endpoints analyzed included mitotic index (MI), replication index (RI), and sister chromatid exchange (SCE). An analysis of variance test (ANOVA) was performed to evaluate the results. A significant decrease in MI and RI was observed compared with negative control cultures, respectively, (p < 0.05, p < 0.01). It is found that SCE frequency increases compared with negative control. There is no significant difference between negative control and drinking water samples and among drinking water samples for sister chromatid exchange induction (p > 0.05).
Keywords :
Replication index , mitotic index , Sister chromatid exchange , cytotoxicity , TOXICITY
Journal title :
Food and Chemical Toxicology
Serial Year :
2008
Journal title :
Food and Chemical Toxicology
Record number :
2120131
Link To Document :
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