Title of article :
Protective effect of cactus (Opuntia ficus indica) cladode extract upon nickel-induced toxicity in rats
Author/Authors :
N.Hfaiedh، نويسنده , , Najla and Allagui، نويسنده , , Mohamed Salah and Hfaiedh، نويسنده , , Mbarka and Feki، نويسنده , , Abdelfattah El and Zourgui، نويسنده , , Lazhar and Croute، نويسنده , , Françoise، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
3759
To page :
3763
Abstract :
The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl2 solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). icant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.
Keywords :
Antioxidant enzymes , Cholesterol , Triglycerides , LDH , ALT , AST , nickel , Cactus (Opuntia ficus indica) cladodes
Journal title :
Food and Chemical Toxicology
Serial Year :
2008
Journal title :
Food and Chemical Toxicology
Record number :
2120518
Link To Document :
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