Author/Authors :
Jung، نويسنده , , Won Kyo and Choi، نويسنده , , Inhak and Oh، نويسنده , , Sangtaek and Park، نويسنده , , Sae-Gwang and Seo، نويسنده , , Su-Kil and Lee، نويسنده , , Soo-Woong and Lee، نويسنده , , Dae-Sung and Heo، نويسنده , , Soo-Jin and Jeon، نويسنده , , You-Jin and Je، نويسنده , , Jae-Young and Ahn، نويسنده , , Chang-Bum and Kim، نويسنده , , Jin Soo and Oh، نويسنده , , Kwang-Soo and Kim، نويسنده , , Young-Mog and Moon، نويسنده ,
Abstract :
The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of TNF-α and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L. undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.
Keywords :
red alga , cytokines , airway hyperresponsiveness , Laurencia undulata , asthma
