Pharmacokinetic of sulfaclozine in broiler chickens

In this study, 30-day-old, 14 male broiler chickens were used. Two groups, each comprising 7 animals, were established. While each animal included in the first group was administered sulfaclozine at a dose of 60 mg/kg bw by intravenous route (IV), group 2 was administered sulfaclozine at the same dose but by intracrop route (IC). In group 1, serum sulfaclozine concentrations at 0.083, 0.50, 2, 6, 24 and 72 h were determined to be 99.62 ± 3.31, 83.50 ± 4.22, 72.68 ± 5.02, 58.43 ± 5.39, 38.66 ± 4.04 and 13.14 ± 1.64 μg/ml, respectively, via HPLC. In group 2, serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72 h were determined as 4.33 ± 0.45, 7.95 ± 0.72, 16.46 ± 2.68, 22.88 ± 3.00, 16.03 ± 3.53 and 5.74 ± 0.98 μg/ml, respectively. Statistical analyses revealed that, of all the parameters studied, only A 1 ∗ , A 2 ∗ , α, β, t1/2α, t1/2β, MRT, Vdarea, k12, k21, AUC0→72 and AUC0→∞ differed significantly between the groups (p < 0.05). Compared to intravenous administration, significant increase in t1/2α, t1/2β, MRT and Vdarea, and significant decrease in A 1 ∗ , A 2 ∗ , α, β, k12, k21, AUC0→72 and AUC0→∞ were observed in the group, which was administered sulfaclozine by intracrop route.