Title of article
Chemical investigation of different crude extracts from Teucrium ramosissimum leaves. Correlation with their antigenotoxic and antioxidant properties
Author/Authors
Ben Sghaier، نويسنده , , M. and Bhouri، نويسنده , , W. and Neffati، نويسنده , , A. and Boubaker، نويسنده , , J. and Skandrani، نويسنده , , I. and Bouhlel، نويسنده , , I. and Kilani، نويسنده , , S. and Chekir-Ghedira، نويسنده , , L. and Ghedira، نويسنده , , K.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
11
From page
191
To page
201
Abstract
The effect of extracts obtained from Teucrium ramosissimum leaves on genotoxicity and SOS response induced by aflatoxin B1 (0.5 μg/assay) as well as nitrofurantoin (5 μg/assay) was investigated in a bacterial assay system, i.e., the SOS chromotest with Escherichia coli PQ37. The T. ramosissimum tested extracts exhibited no genotoxicity either with or without the external S9 activation mixture. However, all the extracts, particularly the total oligomers flavonoids (TOF) extract significantly decreased the genotoxicity induced by aflatoxin B1 and nitrofurantoin. Antioxidant capacity of the tested extracts was evaluated using the enzymatic (xanthine/xanthine oxidase assay) (X/XOD) and the non-enzymatic (NBT/Riboflavine assay) systems. TOF extract was the most effective one in inhibiting both xanthine oxidase activity and NBT reduction. Our findings emphasize the potential of T. ramosissimum to prevent mutations and also its antioxidant effect.
Keywords
NBT/Riboflavine , SOS chromotest , antioxidant capacity , Xanthine oxidase activity , Teucrium ramosissimum
Journal title
Food and Chemical Toxicology
Serial Year
2011
Journal title
Food and Chemical Toxicology
Record number
2122460
Link To Document