Title of article :
Rhein protects against acetaminophen-induced hepatic and renal toxicity
Author/Authors :
Zhao، نويسنده , , Yanling and Zhou، نويسنده , , Guang-De and Yang، نويسنده , , Hongbo and Wang، نويسنده , , Jia-Bo and Shan، نويسنده , , Limei and Li، نويسنده , , Rui-sheng and Xiao، نويسنده , , Xiao-He، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
6
From page :
1705
To page :
1710
Abstract :
This study investigated the possible protective effects and mechanism of rhein on Acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats. Treatment of rats with APAP resulted in severe liver and kidney injuries, as demonstrated by drastic elevation of serum glutamate-pyruvate transaminase (GPT), glutamate-oxaloacetic transaminase (GOT), total bilirubin (TBIL), creatinine (CREA), urea nitrogen (UREA) levels and typical histopathological changes including necrosis, phlogocyte infiltration and fatty degeneration in liver, tubules epithelium swelling and severe vacuolar degeneration in kidney. APAP caused oxidative stress, as evidenced by increased reactive oxygen species (ROS) production, nitric oxide (NO) and malondiadehyde (MDA) levels, together with depleted glutathione (GSH) concentration in the liver and kidney of rats. However, rhein can attenuate APAP-induced hepatotoxicity and nephrotoxicity in a dose-dependent manner. Our results showed that GPT, GOT, UREA and CREA levels and ROS production were reduced dramatically, NO, MDA, GSH contents were restored remarkedly by rhein administration, as compared to the APAP alone treated rats. Moreover, the histopathological damage of liver and kidney were also significantly ameliorated by rhein treatment. These findings suggested that the protective effects of rhein against APAP-induced liver and kidney injuries might result from the amelioration of APAP-induced oxidative stress.
Keywords :
Rhein , acetaminophen , Liver and kidney injuries , TOXICITY
Journal title :
Food and Chemical Toxicology
Serial Year :
2011
Journal title :
Food and Chemical Toxicology
Record number :
2122889
Link To Document :
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