Author/Authors :
Li، نويسنده , , Jianyong and Yu، نويسنده , , Yuanguang and Yang، نويسنده , , Yajun and Liu، نويسنده , , Xiwang and Zhang، نويسنده , , Jiyu and Li، نويسنده , , Bing and Zhou، نويسنده , , Xuzheng and Niu، نويسنده , , Jianrong and Wei، نويسنده , , Xiaojuan and Liu، نويسنده , , Zhiqi، نويسنده ,
Abstract :
The subchronic toxicity of aspirin eugenol ester (AEE) was evaluated after 15-day intragastrically administration in rats at daily doses of 50, 1000, and 2000 mg/kg. AEE at low-dose showed no toxicity to the tested rats. Following repeated exposure to medium- or high-dose of AEE, apparent changes were observed in the levels of blood glucose, AST, ALP, ALT and TB in both male and female rats, and appeared to be dose-independent. There were no significant gender differences in most indexes of subchronic toxicity throughout the experimental period with the exception of food consumption and body weight. The no-observed-adverse-effect level (NOAEL) of AEE was considered to be 50 mg/kg/day under the present study conditions.
