Title of article :
In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR
Author/Authors :
Borska، نويسنده , , Sylwia and Chmielewska، نويسنده , , Magdalena and Wysocka، نويسنده , , Teresa and Drag-Zalesinska، نويسنده , , Malgorzata and Zabel، نويسنده , , Maciej and Dziegiel، نويسنده , , Piotr، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
9
From page :
3375
To page :
3383
Abstract :
The benefits of plant polyphenols as chemotherapeutic agents are of great interest due to their possible anti-cancerogenic activities. Results available up to now suggest that flavonoid quercetin induces lethal effect in many types of tumours and may sensitize resistant cells to drugs. The aim of our study was to examine the effect of quercetin on human gastric carcinoma cells and to determine mode of its action. Parental EPG85-257P cell line and its daunorubicin-resistant variant EPG85-257RDB were used as cell models. Our data revealed that quercetin exerted antiproliferative impact on studied cells (with IC50 value of 12 μM after 72 h), mainly through induction of apoptosis. In sensitive cells cytostatic drug and flavonoid had synergistic effects, in EPG85-257RDB cells quercetin acted as a chemosensitizer. Its impact on resistance mechanism involved decrease of P-glycoprotein expression, inhibition of drug transport and downregulation of ABCB1 gene expression. The results demonstrate that quercetin may be considered as a prospective drug to overcome classical resistance in gastric cancer cells.
Keywords :
Quercetin , Cytotoxcity , P-GLYCOPROTEIN , Drug resistance , Human gastric carcinoma cells , apoptosis
Journal title :
Food and Chemical Toxicology
Serial Year :
2012
Journal title :
Food and Chemical Toxicology
Record number :
2124004
Link To Document :
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