Author/Authors :
Amaral، نويسنده , , Guilherme Pires and de Carvalho، نويسنده , , Nelson Rodrigues and Barcelos، نويسنده , , Rômulo Pillon and Dobrachinski، نويسنده , , Fernando and Portella، نويسنده , , Rafael de Lima and da Silva، نويسنده , , Michele Hinerasky and Lugokenski، نويسنده , , Thiago Henrique and Dias، نويسنده , , Glaecir Roseni Mundstock and da Luz، نويسنده , , Sônia Cristina Almeida and Boligon، نويسنده , , Aline Augusti and Athayde، نويسنده , , Margareth Linde and Villetti، نويسنده , , Marcos Antonio and Antunes Soares، نويسنده , , Félix Alexandre and Fachinetto، نويسنده , , Roselei، نويسنده ,
Abstract :
The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this plant, more commonly known as rosemary, has attracted the interest of the scientific community due to its numerous pharmacological properties and their potential therapeutic applications. Here, we tested the preventive effects of eeRo against gastric ulcer induced by 70% ethanol in male Wistar rats. In addition, we aimed to clarify the mechanism involved in the preventive action of the eeRo in gastric ulcers. Based on the analysis of markers of oxidative damage and enzymatic antioxidant defense systems, the measurement of nitrite and nitrate levels and the assessment of the inflammatory response, the eeRo exhibited significant antioxidant, vasodilator and antiinflammatory properties.
