Author/Authors :
-، - نويسنده Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Karami, Mohammad , -، - نويسنده Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Karimian Nokabadi, Faezeh , -، - نويسنده Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Ebrahimzadeh, Mohammad Ali , -، - نويسنده Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Naghshvar, Farshad
Abstract :
Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.
