Title of article
Preparation and Quality Control of 68Ga-Citrate for PET Applications
Author/Authors
-، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Aghanejad, Ayuob , -، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Jalilian, Amir , -، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Ardaneh, Khosro , -، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Bolourinovin, Fatemeh , -، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Yousefnia, Hassan , -، - نويسنده Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Bahrami-Samani, Ali
Issue Information
دوفصلنامه با شماره پیاپی 0 سال 2015
Pages
8
From page
99
To page
106
Abstract
-
Abstract
Objective(s): In nuclear medicine studies, gallium-68 (68Ga) citrate has been recently known as a suitable infection agent in positron emission tomography (PET). In this study, by applying an in-house produced 68Ge/68Ga generator, a simple technique for the synthesis and quality control of 68Ga-citrate was introduced; followed by preliminary animal studies. Methods: 68GaCl3 eluted from the generator was studied in terms of quality control factors including radiochemical purity (assessed by HPLC and RTLC), chemical purity (assessed by ICP-EOS), radionuclide purity (evaluated by HPGe), and breakthrough. 68Ga-citrate was prepared from eluted 68GaCl3 and sodium citrate under various reaction conditions. Stability of the complex was evaluated in human serum for 2 h at 370C, followed by biodistribution studies in rats for 120 min. Results: 68Ga-citrate was prepared with acceptable radiochemical purity (>97 ITLC and >98% HPLC), specific activity (4-6 GBq/mM), chemical purity (Sn, FeConclusion: This study demonstrated the possible in-house preparation and quality control of 68Ga-citrate, using a commercially available 68Ge/68Ga generator for PET imaging throughout the country.
Journal title
Asia Oceania Journal of Nuclear Medicine and Biology
Serial Year
2015
Journal title
Asia Oceania Journal of Nuclear Medicine and Biology
Record number
2145122
Link To Document