Polyaniline–bismuth oxide nanocomposite sensor for quantification of anti-parkinson drug pramipexole in solubilized system

In this study, a new sensor polyaniline–bismuth oxide (PANI–Bi2O3) nanocomposite has been fabricated and characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). SEM was used to provide information about the morphology of the PANI–Bi2O3 nanocomposite. Cyclic voltammetric studies of electroactive species i.e. K3Fe(CN)6 demonstrate almost reversible electrochemical behaviour, with diffusion controlled mass transfer process in the double layer region of the electrode. EIS studies revealed that PANI–Bi2O3/GCE having lower charge transfer resistance which leads to higher electrocatalytic activity. This modified electrode was successfully used for the detection of pramipexole in pharmaceutical formulation in sodium lauryl sulphate (SLS) in Britton Robinson (BR) buffer at pH 4.5. The ease of fabrication, excellent electrochemical performance and high electroactive surface area are the promising features of the fabricated sensor.