Author/Authors :
Maghsoodlou، Malek Taher نويسنده , , Hazeri، Nourallah نويسنده Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan, P. O. Box 98135-674, Zahedan, Iran , , Fereidooni، Elham نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran , , Salahi، Sajjad نويسنده Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan, P. O. Box 98135-674, Zahedan, Iran , , Mahmoudabadi، Nasrin نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran , , Khorshidi، Naeime نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran. , , Aboonajmi، Jasem نويسنده Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran , , Lashkari، Mojtaba نويسنده Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran. ,
Abstract :
Facile and versatile procedures have been explored for the synthesis of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones. These protocols employ the one-pot multi-component condensation of arylaldehydes and aromatic amines with B-keto esters and isatoic anhydride in chloroacetic acid, respectively. The reactions proceeded smoothly to generate the corresponding products in high yield. We have found that the use of chloroacetic acid as catalyst results in a remarkable beneficial effect on the reaction, allowing it to be performed without the need of any co-catalyst, which is the case in other similar reported methodologies. In addition, the preparation of 2,3-dihydro-4(1H)-quinazolinones derivatives from the reaction of arylaldehydes and anthranilamide in the presence of mentioned catalyst is reported.
