مرکز منطقه ای اطلاع رساني علوم و فناوري - The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis

Author/Authors :

-، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Henriques, Andreia , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Arantes-Rodrigues, Regina , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Faustino-Rocha, Ana I , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Teixeira-Guedes, Catarina I , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Pinho-Oliveira, Jacinta , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Talhada, Daniela , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Teixeira, José H , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Andrade, Andreia , -، - نويسنده Department of Zootechnics, University of Tr?s-os-Montes and Alto Douro, 911 Vila Real, Portugal Center for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, PortugalCentre for the Research and Technology Colaço, Bruno , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, Portugal Paiva-Cardoso, Maria N , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, PortugalCenter for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, PortugalCentre for the Research and Pires, Maria J , -، - نويسنده Chemistry Research Center, CQ-VR, University of Tr?s-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal MVD Ferreira, Ana , -، - نويسنده Chemistry Research Center, CQ-VR, University of Tr?s-os-Montes and Alto Douro, 5001-801, Vila Real, Portugal Nunes, Fernando M , -، - نويسنده Department of Veterinary Sciences, ECAV, University of Tr?s-os-Montes and Alto Douro, 5001-911, Vila Real, PortugalCenter for the Study of Animal Sciences (CECA), University of Porto, 4485-661, Porto, PortugalCentre for the Research and Oliveira, Paula A

Abstract :

Objective(s):Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice. Materials and Methods: The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks. Results:Animals from groups BBN+GT and BBN only developed preneoplastic lesions. Conclusion:We did not observe any effects by GT infusion administration on urinary bladder cancer development.