Author/Authors :
-، - نويسنده Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Orthodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Shirazi, Mohsen , -، - نويسنده Department of Pharmacology and Toxicology, University of Otago, P.O. Box 913, Dunedin, New Zealand Alimoradi, Houman , -، - نويسنده Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Kheirandish, Yasaman , -، - نويسنده Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran Etemad?Moghadam, Shahroo , -، - نويسنده Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran Alaeddini, Mojgan , -، - نويسنده Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Meysamie, Alipasha , -، - نويسنده Department of Orthodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatahi Meybodi, Seyed Amir Reza , -، - نويسنده Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Dehpour, Ahmad Reza
Abstract :
Objective(s):Pantoprazole, is a proton pump inhibitor (PPI) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. The aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (OTM) in rats. Materials and Methods: A time course study was established using 72 rats which were divided into six groups of 12 samples each (four: vehicle; eight: pantoprazole + vehicle). Pantoprazole at a dose of 200 mg/kg suspended in carboxymethyl cellulose (0.25 percent) was administered by a gastric tube. The upper incisors and first molars were ligated by a 5 mm nickel-titanium closed-coil spring to deliver an initial force of 60 g. Animals were euthanized two weeks after orthodontic treatment followed by assessment of tooth movement and histomorphometric evaluation of the detached maxillae. Lateral skull radiographs were obtained once a week, starting from the first day to the 6th week of the study. OTM and bone density data were analyzed using independent sample t-test and repeated measures ANOVA. Results: No significant changes in OTM measurements and optical density were observed in vehicle-receiving animals during the study (P=0.994). OTM was significantly increased after six weeks pantoprazole therapy which continued until the 7th week of the experiment (P=0.007). Optical density significantly increased in the pantoprazole-treated rats after six weeks. Conclusion: Long term PPI therapy at high doses could lead to osteoporosis and enhanced OTM.
