Title of article
Identification of MCP/CD46 analogue on bovine erythrocytes using the new monoclonal antibody IVA-520
Author/Authors
Antal?kov?، نويسنده , , Jana and Simon، نويسنده , , Michal and Jankovi?ov?، نويسنده , , Jana and Horovsk?، نويسنده , , ?ubica، نويسنده ,
Issue Information
سالنامه با شماره پیاپی سال 2007
Pages
5
From page
155
To page
159
Abstract
MCP/CD46 is a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system that has been identified on all human peripheral blood cells except erythrocytes. In this paper, we describe the identification of bovine CD46 on all blood cells, including erythrocytes, with the newly prepared monoclonal antibody IVA-520. This antibody cross-reacts with human and pig cells. Furthermore, the molecule identified by IVA-520 functionally behaves as the MCP molecule, showing cofactor activity for the factor I-mediated cleavage of bovine C3 complement factor.
Keywords
MCP/CD46 , Bovine , monoclonal antibody
Journal title
Veterinary Immunology and Immunopathology
Serial Year
2007
Journal title
Veterinary Immunology and Immunopathology
Record number
2163291
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