Title of article :
Astaxanthin stimulates cell-mediated and humoral immune responses in cats
Author/Authors :
Park، نويسنده , , Jean Soon and Mathison، نويسنده , , Bridget D. and Hayek، نويسنده , , Michael G. and Massimino، نويسنده , , Stefan and Reinhart، نويسنده , , Gregory A. and Chew، نويسنده , , Boon P. and Mathison، نويسنده ,
Issue Information :
سالنامه با شماره پیاپی سال 2011
Pages :
7
From page :
455
To page :
461
Abstract :
Astaxanthin is a potent antioxidant carotenoid and may play a role in modulating immune response in cats. Blood was taken from female domestic shorthair cats (8–9 mo old; 3.2 ± 0.04 kg body weight) fed 0, 1, 5 or 10 mg astaxanthin daily for 12 wk to assess peripheral blood mononuclear cell (PBMC) proliferation response, leukocyte subpopulations, natural killer (NK) cell cytotoxic activity, and plasma IgG and IgM concentration. Cutaneous delayed-type hypersensitivity (DTH) response against concanavalin A and an attenuated polyvalent vaccine was assessed on wk 8 (prior to vaccination) and 12 (post-vaccination). There was a dose-related increase in plasma astaxanthin concentrations, with maximum concentrations observed on wk 12. Dietary astaxanthin enhanced DTH response to both the specific (vaccine) and nonspecific (concanavalin A) antigens. In addition, cats fed astaxanthin had heightened PBMC proliferation and NK cell cytotoxic activity. The population of CD3+ total T and CD4+ T helper cells were also higher in astaxanthin-fed cats; however, no treatment difference was found with the CD8+ T cytotoxic and MHC II+ activated lymphocyte cell populations. Dietary astaxanthin increased concentrations of plasma IgG and IgM. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune responses in cats.
Keywords :
inflammation , FELINE , Astaxanthin , immunity , antioxidants
Journal title :
Veterinary Immunology and Immunopathology
Serial Year :
2011
Journal title :
Veterinary Immunology and Immunopathology
Record number :
2166129
Link To Document :
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