Author/Authors :
Moti، Mahtab نويسنده
Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
, , Amini، Leila نويسنده Department of Midwifery & Reproductive Health, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran , , Mirhoseini Ardakani، Soheila Sadat نويسنده
Department of Biology, College of Basic Sciences, Karaj Branch, Islamic Azad University, Alborz, Iran.
, , Kamalzadeh، Sara نويسنده
Department of Biology, College of Basic Sciences, Karaj Branch, Islamic Azad University, Alborz, Iran.
, , Masoomikarimi، Masoomeh نويسنده
Department of Immunology, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
, , jafarisani، Moslem نويسنده
Department of Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
,
Abstract :
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
