Title of article :
Comparison of serum levels of Tri‐iodothyronine (T3), Thyroxine (T4), and Thyroid‐Stimulating Hormone (TSH) in preeclampsia and normal pregnancy
Author/Authors :
Khadem، Nayereh نويسنده , , Ayatollahi، Hossein نويسنده , , Vahid Roodsari، Fatemeh نويسنده Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Vahid Roodsari, Fatemeh , Ayati، Sedigheh نويسنده Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Ayati, Sedigheh , Dalili، Ehsan نويسنده General Physician, Mashhad University of Medical Sciences, Mashhad, Iran. Dalili, Ehsan , Mohajeri، Taraneh نويسنده Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Mohajeri, Taraneh , Shakeri، Mohamad Taghi نويسنده Immuno-Biochemistry Lab, Immunology Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran , , Shahabian، Masoud نويسنده General Physician, Mashhad University of Medical Sciences, Mashhad, Iran. Shahabian, Masoud
Abstract :
مقدمه: تغييرات فيزيولوژيك غده تيروييد در دوران بارداري به عنوان يكي از عوامل پاتوفيزيولوژيك پره اكلامپسي مطرح شده است.
هدف: هدف از اين مطالعه مقايسه سطح سرمي هورمون هاي TSH، FT4، FT3 در زنان مبتلا به پره اكلامپسي و زنان حامله نرمال مي باشد.
مواد و روش ها: در اين مطالعه مورد-شاهدي، 40 زن حامله نرمال و 40 زن مبتلا به پره اكلامپسي در تريمستر سوم حاملگي مورد ارزيابي و سطح سرمي هورمون هاي TSH، FT4، FT3 در آن ها مورد مقايسه قرار گرفت. سپس اطلاعات با استفاده از نرم افزار SPSS و آزمون هاي t-student، Chi-square، Independent sample T test و Bivariate correlation test آناليز آماري شدند. 05/0?p از نظر آماري معني دار تلقي گرديد.
نتايج: ميانگين سني بين دو گروه تفاوت معني داري نداشت (297/0=p). دو گروه نيز از نظر پاريته تفاوت معني داري نداشتند (206/0=p). همچنين دو گروه زنان حامله نرمال و پره اكلامپسي از نظر سطح هورمون ها (803/0=p، pg/ml 41/1 pg/ml Vs. 381/1) FT3، (834/0=p، pg/ml 96/0 pg/ml Vs. 95/0) FT4 و (386/0=p، ?IU /ml 10/3 ?IU/ml Vs. 51/3) TSH با هم متفاوت نبودند.
نتيجه گيري: يافته هاي مطالعه حاضر از اين فرضيه كه تغيير در سطح سرمي هورمون هاي TSH، FT4، FT3 مي تواند علت احتمالي پره اكلامپسي باشد، حمايت نمي كند.
Abstract :
Background: The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia.
Objective: The aim of this study was comparison of serum levels of Tri?iodothyronine (T3), Thyroxine (T4), and Thyroid?Stimulating Hormone (TSH) in preeclampsia and normal pregnancy.
Materials and Methods: In this case?control study, 40 normal pregnant women and 40 cases of preeclampsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 (FT3), Free T4 (FT4) and TSH. The data was analyzed by SPSS software with the use of t?student, Chi?square, Independent sample T-test and Bivariate correlation test. p?0.05 was considered statistically significant.
Results: The mean age was not statistically different between two groups (p=0.297). No significant difference was observed in terms of parity between two groups (p=0.206). Normal pregnant women were not significantly different from preeclampsia cases in the view of FT3 level (1.38 pg/ml vs. 1.41 pg/ml, p=0.803), FT4 level (0.95 pg/ml vs. 0.96 pg/ml, p=0.834) and TSH level (3.51 ?IU/ml vs. 3.10 ?IU/ml, p=0.386).
Conclusion: The findings of the present study do not support the hypothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclampsia.
