Rapid and efficient one-pot synthesis of spiro[indoline-3,4′-pyrano[2, 3-c]pyrazole] derivatives catalyzed by l-proline under ultrasound irradiation

A rapid and efficient ultrasound-promoted one-pot synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives is described here. The reaction of substituted phenylhydrazine and dialkyl acetylenedicarboxylate with substituted isatin and malononitrile is catalyzed by l-proline to give good-to-excellent yields in water/ethanol (v/v, 1:1) at room temperature.