Author/Authors :
Yu، نويسنده , , Hung-Man and Yeh، نويسنده , , Hsin-Pei and Chang، نويسنده , , Tien-Kui and Huang، نويسنده , , Kuang-Liang and Chuang، نويسنده , , Kuo-Tang and Liu، نويسنده , , Ren-Shen and Wang، نويسنده , , Shyh-Jen and Hwang، نويسنده , , Jeng-Jong and Chi، نويسنده , , Kwan-Hwa and Chen، نويسنده , , Fu-Du and Lin، نويسنده , , Wuu-Jyh and Chen، نويسنده , , Chin-Hsiung and Wang، نويسنده , , Hsin-Ell، نويسنده ,
Abstract :
This study aims to assess whether emulsion of [125/131I]IUdR and lipiodol (IUdR/LP) can improve delivery of IUdR into hepatoma.
s
ro release profile of IUdR from IUdR/LP to serum was performed. IUdR/LP was injected into N1-S1 hepatoma-bearing SD rat via hepatic artery and IUdR/normal saline (IUdR/NS) was used for comparison. Biodistribution, autoradiography, imaging and tumor DNA incorporation assay were performed. The radioactive metabolites in plasma and urine were analyzed. Radiation doses to tumor and organs were estimated.
s
eleased from lipiodol into serum was fast. There were longer retention, more DNA incorporation and higher radiation dose of IUdR in the tumor by using IUdR/LP. IUdR/LP deposited deep in the hepatomas. Only free iodide was found in the plasma and urine after injection of IUdR/LP.
sions
c artery injection of IUdR/LP emulsion could definitely enhance the tumor cell uptake and incorporation to DNA of *IUdR, prolong the tumor retention time and increase radiation dose to tumor. IUdR/LP may be an effective therapeutic agent for the treatment of hepatic tumors.
Keywords :
Iododeoxyuridine , Radionuclide therapy , Lipiodol , Auger electron , Hepatoma
