Author/Authors :
Sabbaghziarani، Fatemeh نويسنده Tehran University of Medical Sciences Sabbaghziarani, Fatemeh , Rasapour، Sharareh نويسنده Khwarizmi University Rasapour, Sharareh , Mortezaee، Keywan نويسنده Tehran University of Medical Sciences Mortezaee, Keywan , Oryan، Shahrbano نويسنده Department of Chemistry, Science and Research Campus, Tehran, Iran , , Sharifzadeh، Mohammad نويسنده , , Khanavi، Mahnaz نويسنده , , Hassanzadeh، Gholamreza نويسنده Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract :
Introduction: Alzheimer disease is a progressive and irreversible neuropsychiatric disorder.
Melissa Officinalis improves anxiety and clinical dementia symptoms caused by AD; therefore,
the purpose of the present study was to evaluate the effect of Mellisa extract on spatial memory
deficit induced by STZ in MWM examination of male wistar rats. Methods: In the present study, 112 male wistar rats (220-270g) were used. Spatial learning
deficit was induced by bilateral ICV injection of STZ (3mg/kg) via cannula; then, the Melissa
extract in different doses administrated by gavage; and Morris Water Maze for measurement of
spatial learning parameters was performed. Results: The results of this study demonstrated that gavage of the 200mg/kg of Melissa
officinalis in combination with STZ, followed by significant reduction in two parameters: Time
and Distance. Conclusion: Totally, the data indicate possible therapeutic value of M. officinalis extract on
spatial learning improvement.
