Author/Authors :
Mohamadi، Forouzan نويسنده Kashan University of Medical Sciences Mohamadi, Forouzan , Nikzad، Hossein نويسنده Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran , , Taherian، Aliakbar نويسنده Obstetric and Gynecology Department, Isfahan University of Medical Sciences, Isfahan, Iran , , Taghizadeh، Mohsen نويسنده Department of Biochemistry and Nutrition, Kashan University of Medical Sciences, Kashan, Iran , , Azami Tameh، Abolfazl نويسنده Anatomy Department, Anatomical Sciences Research Center, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran , , Naderian، Homayon نويسنده Kashan University of Medical Sciences Naderian, Homayon , Atlasi، Mohammad Ali نويسنده Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran ,
Abstract :
Introduction: Cyclophosphamide is a chemotherapy drug with several side effects on various
organs such as male reproductive system that can cause infertility. In this study, we assessed
combined effect of ginger and pumpkin extractson rat testis after CP injection. Methods: Forty adult male rats were randomly divided into 4 groups: The control group
received intraperitoneal injection of isotonic saline solution. The cyclophosphamide (CP) group
received a single dose of cyclophosphamide (100 mg kg_1BW) intraperitoneally. Combined
extracts (ginger+ pumpkin) group received orally 300 mg combined extracts and combined
extracts(ginger+ pumpkin) +CP groups received orally 300 mg combined extracts for a period
of 6 weeks after CP injection. Results: Our results showed that although ginger extract could not change testis weight,
testosterone, malondialdehyde (MDA) and ROS, antioxidant level in serum was increased
significantly. Epithelium thickness and tube diameter were decreased in combined groups with
or without CP in comparison to control group. The combined extract could improve histological
changes in both combined extract and combined extract+ CP compared to CP group, which
could be attributed to the higher serum level of antioxidants. Conclusion: The administration of combined extracts
