Author/Authors :
Dahim، Hajar نويسنده Department of Pathology, Shahid Beheshti Hospital, Isfahan, Iran , , Shahani، Kahin نويسنده department of biochemistry Shahani, Kahin , Sabanizadeh، Ahmad نويسنده department of anatomy Sabanizadeh, Ahmad , Salahshoor، Reza نويسنده Department of Anatomy, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran , , Jalili، Cyrus نويسنده Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran , , Taghavi، Mohammad-Mohsen نويسنده Department of Anatomy, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Taghavi, Mohammad-Mohsen , Kazemi Arababadi، Mohammad نويسنده , , Shariati Kohbanani، Mahdi نويسنده PhD in Anatomy, Department of Anatomy Shariati Kohbanani, Mahdi , Taghipour، Zahra نويسنده Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , , Jafarineveh، Hamidreza نويسنده PhD student in Anatomy, Department of Anatomy Jafarineveh, Hamidreza
Abstract :
Introduction: Endometriosis is a prevalent gynecological disorder among women which is
diagnosed by the growth of endometrial tissue outside of uterus and is mainly accompanied
by severe pelvic pain and infertility. P53 also known as cellular tumor antigen P53 inside
codons 11, 72 and 248 are contained with single nucleotide changes in which tends to be nearly
rampant.This will probably be increasing the chances of endometriosis infection to some great
extent.
Our aim was to evaluate the connection between endometriosis and polymorphism inside the
codons 11, 72 and 248 of P53 gene. Methods: In this study, single nucleotide changes in codons 11, 72 and 284 of TP53 gene
among 44 persons infected with endometriosis and the same studying population for noninfected
group have been examined. After primer design and amplification of polymorphic
sequences by PCR, the polymorphisms of related codons have been evaluated by the digestion
method (RFLP). Results: In this study on the codon 72, there were seen differences in the distribution of genotype
frequencies of normal polymorphic subjects and control subjects with endometriosis. At codons
11 and 248, there were observed no significant correlations between polymorphic and normal
genotypes of endometriosis and non-endometriosis groups. Conclusion: According to the results, we can say that probably polymorphism
