Author/Authors :
Baghaei ، Fahimeh نويسنده Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. , , Shojaei ، Setareh نويسنده Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. , , Afshar-Moghaddam، Noushin نويسنده , , Zargaran، Massoumeh نويسنده Department of Oral and Maxillofacial Pathology, Dental Research Center, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran , , Rastin، Verisheh نويسنده Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Kurdestan University of Medical Sciences, Sanandaj, Iran. , , Nasr Esfahany، Mohsen نويسنده Faculty of Chemical Engineering, Isfahan University of Technology, Isfahan, I.R. IRAN , , Moghimbeigi، Abbas نويسنده Dept. of Biostatistics & Epidemiology, Hamedan University of Medical Sciences ,
Abstract :
Statement of the Problem: Lichen planus is a mucocutaneous disease that is relatively common in middle aged indi-viduals. Some studies have shown that oral lichen planus has a potential to progress to squamous cell carcinoma.p21 is a cyclin-dependent kinase inhibitor that regulates the cell cycle, thus it acts as an inhibitor in cell proliferation.
Purpose: This study was aimed to evaluate and compare the immunostaining of p21 (as a proliferation inhibitory fac-tor) in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).
Materials and Method: In this descriptive cross-sectional study, p21expression was investigated in 24 samples of oral lichen planus (OLP), 24 samples of oral squamous cell carcinoma (OSCC) and 24 samples of oral epithelial hyperplasia (OEH) by employing immunohistochemical staining.
Results: The mean percentage of p21-positive cells in OSCC (54.5±6.6) was significantly higher than that in OLP (32.8±6.08) and OEH (9.4±3.8). Moreover, OLP samples expressed p21 significantly higher than the OEH. Kruskal Wallis test revealed a statistically significant difference between the groups regarding the intensity of staining (p < 0.001).
Conclusion: According to the findings of this study, the expression of p21 might be related to the potential carcinogenic transformation of lichen planus to SCC. Therefore, continuous follow-up periods for OLP are recommended for di-agnosis of the malignant transformations in early stages.
