Author/Authors :
Bakhtiari، Abbas نويسنده Hamadan University of Medical Sciences , , Hosseinipanah، Seyed Mohammad نويسنده Hamadan University of Medical Sciences , , Mohammadi Roushandeh، Amaneh نويسنده ,
Abstract :
Background: After abdominal surgery, postoperative adhesion is a serious problem
that threats the patients. The Present study evaluated the protective effects of morphine
on abdominal adhesion in an experimental model in rat. Materials: An experimental
intraabdominal adhesion model was created in 24 adult male rats by ischemic bottom
method. The animals were divided into three groups. The control group was not
treated by morphin. In the morphine group, the animals received morphine as 10
mg/kg once a day for three days after surgery. In group 3, the addicted animals to
morphine received morphine as 10 mg/kg daily after surgery. Drug dependency was
confirmed by naloxone. Adhesions were evaluated by nair and swollon scoring system
10 days after surgery. Results: There was a significant differences regard to the length
(P < .05), thickness (P < .05), and severity of adhesions (P < .05) among the control,
morphine, and morphine-addicted groups. Conclusion: Morphine reduced the severity
of postoperative adhesions the present study. Morphine could affect postoperation
adhesion through suppression of inflammation. It is suggested that opioid receptor(s)
might involve in this process. Therefore, selective ligands could be used and offer a
pharmacologic strategy in preventing adhesion formation.
