Morphine Decreased Peritoneal Adhesion in Addicted Male Rats after Abdominal Surgery

Background: After abdominal surgery, postoperative adhesion is a serious problem that threats the patients. The Present study evaluated the protective effects of morphine on abdominal adhesion in an experimental model in rat. Materials: An experimental intraabdominal adhesion model was created in 24 adult male rats by ischemic bottom method. The animals were divided into three groups. The control group was not treated by morphin. In the morphine group, the animals received morphine as 10 mg/kg once a day for three days after surgery. In group 3, the addicted animals to morphine received morphine as 10 mg/kg daily after surgery. Drug dependency was confirmed by naloxone. Adhesions were evaluated by nair and swollon scoring system 10 days after surgery. Results: There was a significant differences regard to the length (P < .05), thickness (P < .05), and severity of adhesions (P < .05) among the control, morphine, and morphine-addicted groups. Conclusion: Morphine reduced the severity of postoperative adhesions the present study. Morphine could affect postoperation adhesion through suppression of inflammation. It is suggested that opioid receptor(s) might involve in this process. Therefore, selective ligands could be used and offer a pharmacologic strategy in preventing adhesion formation.