Title of article
Tramadol hydrochloride/montmorillonite composite: Preparation and controlled drug release
Author/Authors
Chen، نويسنده , , Youmei and Zhou، نويسنده , , Anning and Liu، نويسنده , , Bo and Liang، نويسنده , , Jun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
5
From page
108
To page
112
Abstract
The adsorption of tramadol hydrochloride (TH) by montmorillonite (MMT) was investigated, to obtain a controlled drug release system. The adsorption isotherm was fitted by the Langmuir model and followed the pseudo-second-order kinetics. The composite was characterized by XRD, FTIR and TG-DTA. TH was intercalated into MMT in vertical orientation giving a basal spacing of 1.99 nm. Release of the intercalated TH was studied in simulated gastric fluid (SGF, pH = 1.2) and simulated intestinal fluid (SIF, pH = 7.4) at 37 °C. Controlled release of TH from TH/MMT was observed.
Keywords
Tramadol hydrochloride , controlled drug release , Montmorillonite , Adsorption , intercalation
Journal title
Applied Clay Science:an International Journal on the Application...
Serial Year
2010
Journal title
Applied Clay Science:an International Journal on the Application...
Record number
2223047
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