Title of article
Białaczkowe komórki macierzyste
Author/Authors
B. and Adamczyk-Cioch، نويسنده , , Maria and Radomska، نويسنده , , Karolina، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
5
From page
161
To page
165
Abstract
Acute myeloid leukaemia (AML) is a neoplasm originating in early haematopoietic progenitor cells. Each AML clone contains a subpopulation of leukaemic stem cells (LSCs). LSCs have the capacity to repopulate AML in NOD/SCID mice and regrow leukaemia in patients after remission period. LSCs are characterized by CD34+CD38-Lin-CD33+/-CD123+ immunophenotype. The currently available data show that LSCs play a pivotal role in drug resistance. Many studies and clinical trials are being conducted to eradicate LSCs using different forms of target therapy.
Keywords
Therapeutic Targets , Acute myeloid leukaemia , ostra bia?aczka szpikowa , Leukaemic stem cells , cele terapeutyczne , bia?aczkowe kom?rki macierzyste
Journal title
Acta Haematologica Polonica
Serial Year
2014
Journal title
Acta Haematologica Polonica
Record number
2227329
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