Electroanalysis of Mefenamic Acid Using Platinum Powder Composite Microelectrode (PPCM)

Electroanalysis of mefenamic acid using platinum powder composite microelectrode (PPCM) by cyclic voltammetry (CV) method in buffer phosphate has been carried out. PPCM was prepare by Pt powder and PVC in 4 mL tetrahydrofuran (THF) solvent and swirled flatly to homogeneous followed by drying in an oven at 100°C for 3 hours. The mixture was placed in 0.5 cm diameter stainless steel mould and pressed at 10 ton/cm2. Cyclic voltammetry method was performed in a three electrodes system using PPCM as a working electrode, an Ag/AgCl (saturated KCl) as reference electrode and platinum wire as the counter electrode. Electroanalysis of mefenamic acid was performed in a buffer phosphate solution (pH 4). The results of the study showed that the correlation of determination using PPCM electrode for electroanalysis of mefenamic acid was R2=0.995. Precision, LOQ, LOD and recovery of the PPCM towards mefenamic acid were found to be 1.01%, 27.94 ppm, 93.13 ppm and 100.88%, respectively. As a conclusion, PPCM electrode is very good for electroanalysis of mefenamic acid in pharmaceutical product