Author/Authors :
رستمي، اسماعيل نويسنده دانشگاه پيام نور بوشهر , , باقرزاده، مريم نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697, Tehran, Iran Bagherzadeh, Maryam , خدادادي، اكرم نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697, Tehran, Iran Khodadadi, Akram , قبادپور، آي سودا نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697, Tehran, Iran Ghobadpoor, Ay Soda , دهقاني، فاطمه نويسنده , , حيدري ، زهرا نويسنده Hydary, Z , فريدوني، محمود نويسنده , , آب شيريني، زهرا نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697, Tehran, Iran Abshirini, Zahra , تواضع، فاطمه نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697, Tehran, Iran Tavazo, Fatemeh , كشاورز، زهرا نويسنده ,
Abstract :
In this research work, we report the synthesis of macrocyclicdiamides from the reaction of diesters and aliphatic diamines in the presence of caesium carbonate. It has been demonstrated that among the carbonate of alkali metals (Li2CO3, Na2CO3, K2CO3 and CS2CO3), CS2CO3 appears to be the best catalyst for macrocyclization. Diesters with different substitution patterns on the aromatic ring reacted smoothly with diamines under optimal conditions, affording the corresponding macrocycles in high yields. Introducing a rigid group (e.g., sulfone) on the substrate led to somewhat decreased yield. Various substrates proved to be suitable for this macrocyclization reaction, especially, the flexible ones.
