Author/Authors :
Hashemi، Mohammad نويسنده , , Rezaei، Hamzeh نويسنده Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran , , Ali Kaykhaei، Mahmoud نويسنده Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran , , Taheri، Mohsen نويسنده Genetics of Non-communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran Taheri, Mohsen
Abstract :
It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease. The aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor A (TFAM) and MeS. DNA was extracted from peripheral blood of 151 patients with and 149 without MeS. TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP). No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS.
