Author/Authors :
Mohammadi، Shabnam نويسنده Mashhad University of Medical Sciences , , E Zamani، Elaheh نويسنده Gonabad University of Medical Sciences , , Mohadeth، Zohreh نويسنده Gonabad University of Medical Sciences , , Mogtahedi، Faezeh نويسنده Gonabad University of Medical Sciences , , Chopan، Hamideh نويسنده Gonabad University of Medical Sciences , , Moghimi، Farzaneh نويسنده Gonabad University of Medical Sciences , , Mohammadi، Maryam نويسنده Sabzevar University of Medical Sciences , , Karimi، Mehdi نويسنده Gonabad University of Medical Sciences , , Abtahi ، Seyed Hossein نويسنده , , Tavakkoli، Kamyar نويسنده Mashhad University of Medical Sciences , , Mohammadzadeh، Fatemeh نويسنده Mashhad University of Medical Sciences , , Biglari، Hamed نويسنده Qom University of Medical Sciences , , Delshad، Ali Modabberi نويسنده Urology and Nephrology Research Center, Department of Urology, Imam Medical Center, Urmia University of Medical Sciences, Urmia , , Ghayour-Mobarhan، Majid نويسنده MD, PhD, Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science, Mashhad , , Ferns، Gordon AA. نويسنده University of Brighton, BN1 9PH, United Kingdom , , Mohammadzadeh، Alireza نويسنده Gonabad University of Medical Sciences ,
Abstract :
Background: Lead is known to be a highly toxic heavy metal. There are a limited
number of studies investigating the effects of antioxidants on lead-induced kidney
damage. Statins are widely used drugs for the treatment of hypercholesterolaemia, but
they also have other pleiotropic effects. The aim of this study was to determine the
effect of different doses of simvastatin on biochemical and histopathological
parameters in mice exposed to lead. Methods: Forty eight adult male mice were
randomised into six groups. The control group received no lead. Group II was injected
interaperitoneally with 60 mg/kg lead acetate and groups III-VI received
intraperitoneally 5-10-20-40 mg/kg simvastatin plus 60 mg/kg lead. After 14 days, a
stereological study was done in accordance with the principle of Cavalieri and serum
concentrations of urea and creatinine were measured. Data were analyzed using SPSS
software and ANOVA. Results: Lead acetate treatment caused collapse of glomeruli,
glumerulosclerosis, necrosis and vacuolization in renal tubules. Administration of 20
mg of simvastatin reduced the severity of kidney damage. Glomerular volume in the
groups treated with 40 mg of simvastatin was significantly different from the group
treated with lead alone (P =0.001). The number of renal glomeruli in the group treated
with 5 mg of simvastatin were significantly difference compared to the lead treated
group (P =0.027). Serum concentrations of urea and creatinine were not significantly
different in the groups treated with simvastatin compared to the group treated with
lead alone. Conclusions: Treatments with simvastatin Caused protective effects on
renal tissue of mice exposed to lead. However, there was no significant effect on urea
and creatinine levels.
