Title of article :
Hepcidin gene expression induced in the developmental stages of fish upon exposure to Benzo[a]pyrene (BaP)
Author/Authors :
Wang، نويسنده , , Ke-Jian and Bo، نويسنده , , Jun and Yang، نويسنده , , Ming and Hong، نويسنده , , Huasheng and Wang، نويسنده , , Xin-Hong and Chen، نويسنده , , Fang-Yi and Yuan، نويسنده , , Jian-Jun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
7
From page :
159
To page :
165
Abstract :
Hepcidin is known to be expressed in fish with bacterial challenge and iron overload. Here we first report the hepcidin expression induced in the developmental stages from embryo to fry of red sea bream (Pagarus major) and in juvenile black porgy (Acanthopagrus schlegelii B.) upon continuous waterborne exposure to BaP. The gene expression of CYP1A1 and IgL (immunoglobulin light chain) were both measured. Expression of the Pagarus major hepcidin gene (PM-hepc) was increased in post hatch fry at 24 h and 120 h exposure to BaP at concentrations of 0.1, 0.5 and 1.0 μg/l, respectively. The gene expression pattern was comparable to that of CYP1A1 but different from that of IgL. In addition, a high number of AS-hepc2 transcripts (Acanthopagrus schlegelii B. hepcidin gene) were detected in the liver upon exposure to 1.0 μg/l BaP. This study demonstrates that hepcidin gene expression is significantly induced in BaP-exposed red sea bream and black porgy.
Keywords :
mRNA expression , hepcidin , fishes
Journal title :
Marine Environmental Research
Serial Year :
2009
Journal title :
Marine Environmental Research
Record number :
2255279
Link To Document :
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