CSF Protein Contents and Their Roles in Brain Development

Abstract: In early stages of development, the laminated structure of cerebral cortex is organized by proliferative, morphogenetic, and migratory processes. In these stages, cells within the ependymal lining of neural tube are thought to secrete embryonic cerebrospinal fluid (eCSF). As the neural tube closes, the choroid plexuses (CPs) secrete proteins such as growth factors, cytokines and morphogenes into the eCSF. The apical neuroepithelium is bathed with this fluid which plays regulatory roles in cortical cell proliferation, differentiation, and maintenance. Because of the eCSF protein contents and their impacts on neurogenesis, we focused on the effect of eCSF growth factors and their changes during brain development. Bibliographic databases including PubMed, Scopus and Google Scholar were searched between years 1990 to 2013 for the keywords “Cerebrospinal fluid” and “Neurogenesis”. In the first step, 200 articles were found, after elimination of duplicates or irrelevant papers 49 papers were selected and reviewed.