Author/Authors :
-، - نويسنده Departments of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hushmand, Mahnaz , -، - نويسنده Departments of Pediatric Asthma and Allergy, Ghaem Hospital,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Behmanesh, Fatemeh , -، - نويسنده Departments of Pediatric Asthma and Allergy, Ghaem Hospital,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ahanchian, Hamid , -، - نويسنده Departments of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Khalesi, Maryam , -، - نويسنده Departments of Pediatrics, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ataei, Alireza
Abstract :
The active form of vitamin D is synthesized in some body organs following sun exposure and dietary intake. Vitamin D exhibits its major and critical effects not only through regulation of calcium and phosphate metabolism but also by influencing on respiratory and immune system. Serum concentrations of 25-hydroxyvitamin D below the optimum limit lead to vitamin D insufficiency or maybe deficiency. These inappropriate concentrations of vitamin D lead to different types of pulmonary diseases such as viral and bacterial respiratory infection, asthma, chronic obstructive pulmonary disease, and cancer. In this review we described the association between vitamin D deficiency and severe therapy resistant asthma. We also reviewed the underlying molecular mechanism of vitamin D deficiency in children with severe- therapy resistant asthma. Based on current information, future clinical trial are needed to study the role of vitamin D supplementation on different groups of patients with severe asthma including infants, children of school age, and ethnic minorities.
