Author/Authors :
Nasri، Sima نويسنده Department of Biology , , Rezai-Zarchi، Saeid نويسنده 1Department of Biology, Payame Noor University, Tehran, IR Iran Rezai-Zarchi, Saeid , Kerishchi، Parisa نويسنده Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran Kerishchi, Parisa , Sadeghi، Safora نويسنده 1Department of Biology, Payame Noor University, Tehran, IR Iran Sadeghi, Safora
Abstract :
Abstract
Background: Now a day, Fe2o3 nanoparticles due to high magnetic property and small size are used in MRI imaging.
Objectives: This study aimed to characterize the effect of iron oxide nanoparticles on sperm parameters.
Materials and Methods: This experiment study was carried out on 75 mature male mice that divided into 4 test groups that received iron oxide nanoparticles at the dose levels of 5, 10, 20, 40 mg/kg intraperitaneally (i.p.) for 2 weeks and a control group. Sperm was collected from epididymis and prepared for analysis.
Results: Fe2o3 nanoparticles cause a meaningful reduction in sperm numbers and mobility in all experimental groups.
Conclusions: Nanoparticles can cause the inflammation of epididymis and increasing of free radicals (Reactive oxygen species: ROS) that can decrease the mobility of the sperms.
