Author/Authors :
Hajmohammadi، Taiebeh نويسنده Resident of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran , , Sadeghi، Masoumeh نويسنده , , Dashti، Masoumeh نويسنده Resident of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran , , Hashemi، Mohammad نويسنده Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran , , Saadatnia، Mohammad نويسنده , , Soghrati، Mojgan نويسنده Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Soghrati, Mojgan , Talaei، Mohammad نويسنده Medical doctor, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran , , Sarrafzadegan، Nizal نويسنده MD, Professor of Cardiology, Isfahan Cardiovascular Research Center, IUMS, Isfahan ,
Abstract :
BACKGROUND: Recent studies have confirmed inflammatory factors and metabolic syndrome
(MetS) as important cardiovascular disease (CVD) risk factors. Recently measurement of carotid
intima-media thickness (IMT) has been used for evaluation of early atherosclerosis. This study
was designed to assess the correlation between IMT with some inflammatory biomarkers, ghrelin
and adiponectin in people with and without MetS in a cohort sample in Isfahan province.
METHODS: Among participants of Isfahan Cohort Study (ICS) by random sampling, 88 participants
were selected and divided into case (with MetS) and control (without MetS) groups. A
questionnaire including demographic data and CVD risk factors was completed for all of the
participants. Physical examination and blood pressure, height, weight and waist circumference
measurements were done for all subjects. Vascular echocardiography was done for evaluation of
IMT of each carotid artery of both sides. Interlukin-6 (IL-6), interlukin-10 (IL-10), highly sensitive
C-reactive protein (hs-CRP), ghrelin and adiponectin levels were measured using ELIZA
method. Data were entered in SPSS15 software and analyzed by t-test, chi square, Pearson correlation
and linear regression analyze.
RESULTS: The mean waist circumference, BMI, systolic blood pressure, diastolic blood pressure,
hs–CRP and IMT of left carotid artery were significantly higher in participants with Mets.
There was significant correlation between left carotid IMT and IL-6 level in all patients
(P = 0.03). After adjustment for age and sex, significant relationship in groups with MetS was only
reported between the left IMT and IL-6 (P = 0.02). There was no relation between IMT and other
inflammatory markers in subjects with and without MetS.
CONCLUSION: Significant correlation between IL-6 and IMT was reported in patients with
MetS. While no significant correlation between IL-10, adiponectin and ghrelin with IMT was observed
in metabolic syndrome group.
