Molecular thermodynamics of hydrophobic effects

There have been two new advances in molecular thermodynamic models of hydrophobic effects. One is an information theory model for predicting free energies of hydrophobic hydration and hydrophobic interactions based on an analysis of density fluctuations in pure liquid water. The second involves the use of proximity approximations to predict water structure around hydrophobic or moderately amphiphilic molecular solutes of arbitrary size and shape. Recently, computer simulation studies of the effect of pressure on water structure and hydrophobic interactions have also been carried out.